KPV

KPV — Anti-Inflammatory Tripeptide

KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment derived from alpha-melanocyte stimulating hormone (α-MSH). Despite being only three amino acids in length, KPV retains the potent anti-inflammatory activity of its parent molecule while being small enough to resist enzymatic degradation and penetrate tissues efficiently. This makes KPV one of the most targeted anti-inflammatory peptides available for research.

Mechanism of Action

KPV exerts anti-inflammatory effects through multiple mechanisms: it inhibits NF-κB nuclear translocation by preventing IκB-α phosphorylation, reduces pro-inflammatory cytokine production (IL-1β, IL-6, TNF-α), and modulates inflammatory cell migration. KPV also interacts with melanocortin receptors, though its anti-inflammatory activity appears partially independent of classical MC receptor binding. Research has demonstrated its ability to cross intestinal epithelial barriers, making it valuable for mucosal inflammation studies.

Research Applications

• NF-κB pathway inhibition and inflammatory signaling
• Mucosal healing and intestinal barrier function
• Cytokine modulation (IL-1β, IL-6, TNF-α reduction)
• Inflammatory bowel disease pathway research
• Skin inflammation and wound healing studies
• Comparative studies with full-length α-MSH

Product Specifications

• Quantity: Per vial
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: USA lab tested, COA available

For laboratory research only. Not for human or animal consumption.