Semax — Nootropic Neuropeptide (ACTH 4-10 Analog)
Semax is a synthetic heptapeptide derived from the ACTH (adrenocorticotropic hormone) fragment 4-10, with the addition of a Pro-Gly-Pro C-terminal tripeptide sequence that enhances metabolic stability and CNS penetration. Originally developed at the Institute of Molecular Genetics in Russia, Semax is one of the most well-characterized nootropic peptides in neuroscience research.
Mechanism of Action
Semax increases brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in the hippocampus and cortex. It modulates serotonergic and dopaminergic neurotransmission, enhances acetylcholine release, and activates MAPK/ERK signaling cascades involved in synaptic plasticity and long-term potentiation. Notably, Semax achieves its nootropic effects without the adrenocortical stimulation typical of ACTH-related peptides.
Research Applications
- BDNF and NGF expression modulation studies
- Cognitive function and memory formation research
- Neuroplasticity and synaptic remodeling
- Neuroprotection in ischemic injury models
- Neurotransmitter system modulation (dopamine, serotonin)
Product Specifications
- Quantity: 10mg per vial
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
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