MOTS-C

MOTS-C — Mitochondrial-Derived Peptide

MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino acid peptide encoded within the mitochondrial genome — one of only a few known mitochondrial-derived peptides (MDPs). Its discovery has opened new frontiers in understanding how mitochondrial DNA communicates with the nuclear genome to regulate systemic metabolism.

Mechanism of Action

MOTS-C activates the AMPK pathway (5′ AMP-activated protein kinase), a master regulator of cellular energy homeostasis. Through AMPK activation, MOTS-C enhances glucose uptake, promotes fatty acid oxidation, and improves mitochondrial respiration. Research has shown that MOTS-C translocates to the nucleus under metabolic stress, where it directly regulates gene expression related to antioxidant response elements (ARE) through interaction with the NRF2 pathway.

Research Applications

• AMPK pathway activation and metabolic regulation
• Exercise mimetic and endurance physiology studies
• Insulin sensitivity and glucose metabolism research
• Mitochondrial-nuclear communication (retrograde signaling)
• Aging biomarker and longevity pathway investigations
• Metabolic stress response mechanisms

Product Specifications

• Quantity: 10-40mg per vial (select option)
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: USA lab tested, COA available

For research purposes only. Not for human use or consumption.