MOTS-C — Mitochondrial-Derived Peptide
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino acid peptide encoded within the mitochondrial genome — one of only a few known mitochondrial-derived peptides (MDPs). Its discovery has opened new frontiers in understanding how mitochondrial DNA communicates with the nuclear genome to regulate systemic metabolism.
Mechanism of Action
MOTS-C activates the AMPK pathway (5′ AMP-activated protein kinase), a master regulator of cellular energy homeostasis. Through AMPK activation, MOTS-C enhances glucose uptake, promotes fatty acid oxidation, and improves mitochondrial respiration. Research has shown that MOTS-C translocates to the nucleus under metabolic stress, where it directly regulates gene expression related to antioxidant response elements (ARE) through interaction with the NRF2 pathway.
Research Applications
- AMPK pathway activation and metabolic regulation
- Exercise mimetic and endurance physiology studies
- Insulin sensitivity and glucose metabolism research
- Mitochondrial-nuclear communication (retrograde signaling)
- Aging biomarker and longevity pathway investigations
- Metabolic stress response mechanisms
Product Specifications
- Quantity: 10-40mg per vial (select option)
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
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