Tesamorelin — Growth Hormone-Releasing Hormone Analog
Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH) consisting of the 44-amino acid sequence of native GHRH with the addition of a trans-3-hexenoic acid group. This modification enhances biological stability while preserving full receptor binding activity, making Tesamorelin a preferred GHRH analog in preclinical growth hormone research.
Mechanism of Action
Tesamorelin binds to GHRH receptors on somatotroph cells in the anterior pituitary gland, activating adenylyl cyclase and elevating intracellular cAMP levels. This cascade stimulates the synthesis and pulsatile secretion of endogenous growth hormone while maintaining the physiological feedback loop. Unlike direct GH administration, Tesamorelin preserves the natural diurnal rhythm of GH release.
Research Applications
- Endogenous growth hormone secretion studies
- Somatotropic axis and pituitary function research
- Visceral adipose tissue metabolism investigations
- IGF-1 signaling and downstream pathway analysis
- Age-related GH decline and sarcopenia studies
Product Specifications
- Quantity: 5mg per vial
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
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