Ipamorelin

Ipamorelin — Selective Growth Hormone Secretagogue

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that selectively stimulates growth hormone release through the ghrelin/GHS receptor (GHSR). What distinguishes Ipamorelin from other GH secretagogues is its remarkable selectivity — it promotes GH release without significantly affecting cortisol, prolactin, or ACTH levels, making it one of the cleanest research tools for isolated GH pathway studies.

Mechanism of Action

Ipamorelin binds to the growth hormone secretagogue receptor (GHSR) on pituitary somatotroph cells, triggering a calcium-dependent signaling cascade that promotes GH vesicle release. Unlike GHRP-6 and GHRP-2, Ipamorelin does not significantly stimulate appetite through ghrelin-mimetic effects and shows minimal interaction with ACTH or cortisol secretion pathways. This selectivity allows researchers to study GH-specific effects without confounding hormonal variables.

Research Applications

• Selective GH secretion and pituitary function studies
• GHS receptor (GHSR) signaling research
• Lean body mass and muscle biology investigations
• Bone mineral density and osteoblast activity studies
• Synergistic studies with GHRH analogs (e.g., CJC-1295)
• Anti-aging and age-related GH decline research

Product Specifications

• Quantity: 5mg per vial
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: USA lab tested, COA available

For research use only. Not for human or animal use.